Cuproptosis Induced by ROS Responsive Nanoparticles with Elesclomol and Copper Combined with ?PD?L1 for Enhanced Cancer Immunotherapy (Adv. Mater. 22/2023)

Immunotherapy In article 2212267, Haihua Xiao, Nianzeng Xing, and co-workers present a novel therapeutic strategy to achieve synergistic cancer immunotherapy via cuproptosis induced by reactive oxygen species (ROS)-responsive nanomedicine loaded with elesclomol copper ([email protected]). With this approach, the tumor microenvironment is reprogrammed, expression of PD-L1 increased, which consequently improves responsiveness immunotherapy.